Figure 3.

Probability of EFS based on ddPCR MRD. ddPCR MRD results were obtained by analyzing 1.5 μg DNA of patients with high MRD (≥ 5.0 × 10^–4) at day +33 and POS-NQ at day +78 by RQ-PCR of IG/TR markers (A). (B), EFS when negative and POS-NQ by ddPCR were cumulatively analyzed. ddPCR = droplet digital polymerase chain reaction; EFS = event-free survival; IG = immunoglobulin; MRD = minimal residual disease; POS-NQ = positive not-quantifiable; RQ-PCR = real-time quantitative polymerase chain reaction; TR = T-cell receptor.