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. 2021 Jan 20;11(2):149. doi: 10.3390/diagnostics11020149

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Interaction network analysis and pathways associated with the five identified metabolites. (A) Interaction map of the annotated metabolites; nodes are color coded for the degree of the metabolite interactions; (B) pathways associated with the most prominent metabolites based on KEGG analysis; (C) pathways associated with the most prominent metabolites based on SMPDB analysis; (D) detailed view of the “Glycine, serine and threonine metabolism” (KEGG map00260) as the most significant pathway according to the KEGG analysis; the numbers in the boxes represent the IDs of annotated metabolites in KEGG database; prominent metabolites as a result of the current analysis are marked in red. Key signaling pathways with p-values < 0.05 were marked in boxes with red font in (B,C).