Table 3.
Heritability of OCD and ADHD factors and their modification of the heritability of TS, OCD, and ADHD diagnoses
| Heritability of diagnoses significantly changed by inclusion of given factor as a covariate | ||||||
|---|---|---|---|---|---|---|
| Factor | h2ra | SE | P-value | TS | OCD | ADHD |
| OCD factors: | ||||||
| OCD F1 (doubts/scrupulosity) | .35 | .03 | 1.25 × 10−27 | X | ||
| OCD F2 (symmetry/exactness) | .37 | .03 | 1.24 × 10−29 | X | X | |
| OCD F3 (contamination) | .31 | .03 | 1.06 × 10−22 | X | ||
| OCD F4 (aggressive urges) | .31 | .03 | 3.89 × 10−28 | X | X | X |
| OCD F5 (fear-of-harm) | .24 | .03 | 3.20 × 10−15 | X | X | |
| OCD F6 (need for sameness) | .20 | .03 | 5.26 × 10−12 | X | ||
| OCD F7 (superstitions) | .23 | .03 | 1.27 × 10−12 | X | ||
| OCD F8 (hoarding) | .33 | .03 | 3.74 × 10−28 | X | X | |
| ADHD factors: | ||||||
| ADHD F1 (inattentive) | .41 | .03 | 1.03 × 10−38 | X | X | X |
| ADHD F2 (hyperactive/impulsive) | .38 | .03 | 8.54 × 10−34 | X | X | X |
ADHD, attention-deficit/hyperactivity disorder; h2r, estimated heritability value; OCD, obsessive-compulsive disorder; SE, standard error; TS, Tourette Syndrome.
‘X’ indicates P≤0.05, uncorrected.
a
Controlling for age, sex, and age×sex