Table 1. List of proteins involved in the cytoplasmic preassembly of axonemal dyneins in human and model organisms and their aliases.
Crosses indicate in which model organism a cytoplasmic preassembly factor was analyzed and if mutations in the orthologous human gene were identified.
| Axonemal dynein preassembly factor | Analyzed in model organisms and identified in Humans | References | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chlamydomonas reinhardtii | Paramecium tetraurelia | Trypanosoma brucei | Schmidtea mediterranea | Drosophila melanogaster | Danio rerio | Oryzias latipes | Xenopus laevi | Mus musculus | Homo sapiens | ||
| CFAP298/Kurly/C21orf59/ CILD26/ FBB18 | x | x | x | x | [26–28] | ||||||
| CFAP300/C11orf70/ CILD38/FBB5 | x | x | x | [29–31] | |||||||
| DNAAF1/LRRC50/ CILD13/ODA7 | x | x | x | x | x | [32–40] | |||||
| DNAAF2/KTU/Kintoun/ C14orf104/CILD10/ PF13 | x | x | x | x | x | [23,25,32,42,52,69,75,78] | |||||
| DNAAF3/C19orf51/ PF22/ CILD2 | x | x | x | [32,41,42] | |||||||
| DNAAF4/DYX1C1/ DYX1/ PF23/CILD25 | x | x | x | x | [42–45] | ||||||
| DNAAF5/HEATR2/ HTR/ CILD18 | x | x | [46–48] | ||||||||
| DNAAF6/PIH1D3/ CXorf41/TWISTER/ CILD36 | x | x | x | [25,49–52] | |||||||
| DNAAF7/ZMYND10/ CILD22 | x | x | x | x | x | [53–57] | |||||
| LRRC6/DNAAF11/ TilB/Seahorse/ CILD19 | x | x | x | x | x | [53,58–64] | |||||
| SPAG1/DNAAF13/ CILD28 | x | x | [65–67] | ||||||||
| TTC12/CILD45 | x | [68] | |||||||||
| PIH1D1/DNAAF14/ MOT48/NOP1/ IDA10/ PIH1 | x | x | [25,52,69] | ||||||||
| PIH1D2/DNAAF15/ Pih1d2 | x | [52] | |||||||||
| RUVBL1/RVB1/Pontin/ Tip49/CrRuvBL1 | x | x | [70–72] | ||||||||
| RUVBL2/RVB2/Reptin/ Tip48 | x | [71,73] | |||||||||
| WDR92/ DNAAF10 | x | x | [74–77] | ||||||||