Figure 2.

Hepatocyte reaction to signals of inflammation, oxidative stress, death and survival and the role of IC inhibitors. Reactive oxygen species (ROS), lipopolysaccharides (LPS), nuclear factor kB (NF-kB), Interleukin (IL: Il-1ß, Il-6), tumor necrosis factor alpha (TNF α), chemokines (IL8; RANTES CCL5: RANTES—Regulated upon Activation, Normal T cell Expressed and presumably Secreted), CC-chemokine ligand 2 (CCL2), specific mitochondrial enzyme succinate dehydrogenase (SDH) and release of cytochrome c, TGF-β—Transforming growth factor beta, VEGF—vascular endothelial growth factor, HGF—hepatocyte growth factor.