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. 2021 Jan 21;9(2):101. doi: 10.3390/biomedicines9020101
ALT alanine aminotransferase = alanine transaminase = glutamic pyruvic transaminase (GPT)
ANA antinuclear antibody
ALP alkaline phosphatase
AST aspartate aminotransferase = aspartate transaminase = glutamic oxalic transaminase (GOT)
BRCA breast cancer susceptibility alleles
CS corticosteroid
CS Tx corticosteroid therapy
CTCAE
CPIH
Common Terminology Criteria for Adverse Events
Check point inhibitor hepatotoxicity
CTLA-4- cytotoxic T lymphocytes associated antigen 4
DC
Dx
dendritic cells
Dexametasone
DILI drug-induced liver injury
DILIN drug-induced liver injury network
dMMR microscope set microsatellite instability high or mismatch repair deficiency
ECM extracellular matrix
EMA European Medicines Agency
FDA United States Food and Drug Administration
FGF fibroblast growth factor
FGFR fibroblast growth factor signaling pathway
FISH Fluorescence In-Situ Hybridization
GI Gastrointestinal
GLDH glutamate dehydrogenase
GGT gamma-glutamyl-transferase
HER2 Human estrogen receptor 2
HMGB1 High-mobility group box 1
ICI immune checkpoint inhibitor
ICOS Inducible T-cell co-stimulator
IL Interleukin
ICH Immuno-Histochemistry
IFN-γ interferon-gamma
KIR2DS2 Killer cell immunoglobulin-like receptor
LFT liver function test
LY403200 hepatitis A virus cellular receptor 2 (HAVCR2)
M-CSFR macrophage colony-stimulating factor
MMF Mycophenolate
MYC Oncogene c-MYC
p53 tumor suppressor protein 53
PD-1 programmed cell death receptor 1
PDL-1 programmed cell death ligand 1
PDL- 2 programmed cell death ligand 2
PIK3CA protein IK3 oncogene
PTEN Phosphatase and Tensin Homolog deleted on Chromosome 10
RANTES Regulated upon Activation, Normal T cell Expressed and presumably Secreted
RUCAM Roussel Uclaf Causality Assessment Method
TBL total bilirubin
TGF- β transforming growth factor β
TIM 3 T-cell immunoglobulin and mucin domain 3 (Tim-3) encoded in germline mutations in HAVCR2
TME tumor microenvironment
TNF-α Tumor necrosis factor alpha
TNFRSF18 Tumor necrosis factor receptor superfamily member 18
Tx Therapeutic agent
UDCA urso-deoxycholic acid
ULN upper limit of normal
VEGF vascular endothelial growth factor.