Table 1.

The differences between autoimmune hepatitis and ICI hepatotoxicity.

	Autoimmune Hepatitis	ICI Hepatotoxicity
Gender	Female predominant	Equal sex incidence
Symptoms	Malaise, jaundice	Fever, rash
Antibody—ANA, ASMA	Positive	Negative or low titer
Gamma globulin level	Increased	Normal range
Histology	Interface hepatitis, fibrosis	Hepatitis (lobular, pan-lobular, centrilobular, granulomatous). Portal fibrosis.
Cell infiltration	Plasma cell: CD4+ CD8+	Histiocyte: CD4+ CD8+
Recurrence after ICI withdrawal	Yes	No

ANA—antinuclear antibody, ASMA—anti-smooth-muscle antibody.