Table 1. Clinicopathologic Characteristics of 103 Participants with 103 Observations.
| Participants | n = 103 |
|---|---|
| Mean age | 63.1 (21–86) |
| Sex | |
| Male:female | 81:22:00 |
| Cause of liver diseases | |
| Hepatitis B virus | 67 (65) |
| Hepatitis C virus | 6 (5.8) |
| Alcohol | 11 (10.7) |
| Others | 19 (18.3) |
| Known cirrhosis | 45 (43.7) |
| Child-Pugh classification | |
| A | 95 (92.2) |
| B | 8 (7.8) |
| AFP level (ng/mL)* | 8.2 (1.1–7466) |
| PIVKA (mAU/mL)* | 35 (11–43913) |
| Observations | n = 103 |
| Size (mm) | 28.2 (11–114) |
| 10–19 | 58 (56.3) |
| ≥ 20 | 45 (43.7) |
| CT/MRI LI-RADS category | |
| LR-3 | 5 (4.9) |
| LR-4 | 21 (20.4) |
| LR-5 | 60 (58.3) |
| LR-M | 17 (16.5) |
| Final diagnosis | |
| HCC | 79 (76.7) |
| Non-HCC malignancy | |
| cHCC-CC | 2 (1.9) |
| IHCC | 11 (10.6) |
| Angiosarcoma | 1 (1) |
| Metastasis | 1 (1) |
| Benign | |
| Dysplastic nodule | 3 (2.9) |
| Adenoma | 2 (1.9) |
| Regenerative nodule | 1 (1) |
| Hemangioma | 1 (1) |
| Focal nodular hyperplasia | 1 (1) |
| Organizing hematoma | 1 (1) |
| Reference standard for diagnosis | |
| Pathological diagnosis | 57 (55.3) |
| Noninvasive | 45 (43.7) |
| Typical image features with more than 1-year stability† | 1 (1) |
*Median value, †Only for diagnosing hemangioma that presented peripheral globular enhancement pattern on CT and MRI with stability (> 1-year). AFP = alpha-fetoprotein, cHCC-CC = combined hepatocellular-cholangiocarcinoma, HCC = hepatocellular carcinoma, IHCC = intrahepatic cholangiocarcinoma, LI-RADS = Liver Imaging Reporting and Data System, LR = LI-RADS, PIVKA = protein induced by vitamin K absence or antagonist