Table 4. Diagnostic Ability of Gd-EOB-MRI with CEUS as a Second-Line Modality to Identify HCC among the at Risk Observations.
| Guidelines | Gd-EOB-MRI | Gd-EOB-MRI, Then CEUS* | P | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Sensitivity | Specificity | Accuracy | Sensitivity | Specificity | Accuracy | Sensitivity | Specificity | Accuracy | |
| All (n = 103) | |||||||||
| EASL | 72.2 | 95.8 | 0.84 | 83.5 | 95.8 | 0.90 | < 0.01 | N/A | < 0.01 |
| (60.9, 81.7) | (78.9, 99.9) | (0.75, 0.90) | (73.5, 90.9) | (78.9, 99.9) | (0.82, 0.95) | ||||
| KLCA-NCC | 86.1 | 87.5 | 0.87 | 91.1 | 87.5 | 0.89 | 0.04 | N/A | 0.04 |
| (76.5, 92.8) | (67.6, 97.3) | (0.79, 0.93) | (82.6, 96.4) | (67.6, 97.3) | (0.82 0.95) | ||||
| Noninvasive diagnostic criteria of CEUS† | CEUS with sulfur hexafluoride | ||||||||
| 60.8 | 100 | 0.80 | |||||||
| (49.1, 71.6) | (85.8, 100) | (0.71, 0.88) | |||||||
| Pathologic proven (n = 57) | |||||||||
| EASL | 61.8 | 95.7 | 0.79 | 76.5 | 95.7 | 0.86 | 0.03 | N/A | < 0.01 |
| (43.6, 77.8) | (78.1, 99.9) | (0.66, 0.88) | (58.8, 89.3) | (78.1, 99.9) | (0.74, 0.94) | ||||
| KLCA-NCC | 73.5 | 86.9 | 0.80 | 82.4 | 86.9 | 0.85 | 0.08 | N/A | 0.04 |
| (55.6, 87.1) | (66.4, 97.2) | (0.68, 0.90) | (65.5, 93.2) | (66.4, 97.2) | (0.73, 0.93) | ||||
| Noninvasive diagnostic criteria of CEUS† | CEUS with sulfur hexafluoride | ||||||||
| 60.8 | 100 | 0.81 | |||||||
| (44.6, 77.8) | (85.2, 100) | (0.68, 0.90) | |||||||
Numbers in parentheses are 95% confidence intervals. *CEUS was performed when MRI presented inconclusive image features for noninvasive diagnosis of HCC, †Non-invasive diagnostic criteria of CEUS were APHE (≥ 1 cm) with mild and late (≥ 60 seconds) washout in CEUS LI-RADS v2017, EASL and KCLA-NCC guideline.