Fig. 2. A representative case of solid-predominant lung adenocarcinoma in the right middle lobe of an 80-year-old male patient.

During 469 days of follow-up, the nodule became enlarged, with a volume change of 292.5%. The calculated VDT and MDT were 232.7 and 224.7 days, respectively. MDT = mass doubling time, VDT = volume doubling time