Table 6. Relevant clinical reports studying effects of caffeine on regadenoson use.

CMR: Cardiac magnetic resonance; BP: Blood pressure

Authors	Methods	Sample size	Primary outcome	Results
Posch et al. [36]	Observational prospective study; patients presenting for regadenoson stress myocardial perfusion imaging were asked their amounts of daily caffeine intake.	101 patients; 89% reported caffeine intake, with 13% reporting heavy caffeine intake (> 400 mg daily)	Chest pain, aminophylline administration, resting/peak heart rate, diastolic BP response	Less chest pain, aminophylline administration, lower resting and peak heart, and lower diastolic BP in caffeine users
Dijk et al. [37]	98 consecutive patients with suspected coronary artery disease referred for either adenosine or regadenoson perfusion CMR were included in this analysis.	33 patients undergoing regadenoson CMR (9 patients with coffee consumptions < 4h, 24 patients with no coffee consumption	T1 reactivity; subtracting T1rest from T1stress	No significant difference in patients who reported no coffee intake compared to patients with less than 4 hours since their last coffee intake