TABLE II.

Linear Growth-Curve Model Predictions for Changes in BMI (kg/m²) per Year on ART

	All regimens		INSTI		NNRTI		PI
Independent variables	Predicted change	P value	Predicted change	P value	Predicted change	P value	Predicted change	P value
Baseline BMI <25
Time	0.51	.000	0.54	.000	0.48	.000	0.54	.001
Age	0.03	.067	0.06	.052	0.02	.369	−0.14	.100
Race/ethnicity (ref. White)
African American	0.27	.298	0.45	.244	0.16	.665	−0.35	.571
Other	0.21	.505	−0.12	.788	0.23	.608	0.60	.262
CD4 (ref. <500 cells/µL)
CD4 ≥ 500	−0.31	.205	−0.25	.443	−0.43	.274	0.88	.191
Viral load (ref. <100,000 c/mL)
Viral load ≥100,000	−0.33	.187	−0.3	.392	0.16	.659	−1.91	.000
Time from HIV diagnosis to ART start	−0.02	.776	−0.03	.770	0.01	.905	0.02	.386
Anchor class (ref. INSTI)
NNRTI or PI	−0.15	.515	-	-	-	-	-	-
Baseline BMI ≥25
Time	0.29	.000	0.54	.000	0.10	.211	0.39	.006
Age	0.10	.000	0.12	.004	0.09	.008	0.07	.293
Race/ethnicity (ref. White)
African American	0.99	.016	1.85	.007	0.50	.358	1.53	.186
Other	0.52	.249	0.89	.228	0.36	.572	1.95	.086
CD4 (ref. <500 cells/µL)
CD4 ≥ 500	0.64	.079	0.98	.083	0.25	.627	0.00	.999
Viral load (ref. <100,000 c/mL)
Viral load ≥100,000	−0.43	.297	−0.31	.702	−0.69	.202	1.50	.119
Time from HIV diagnosis to ART start	0.09	.139	0.34	.005	0.00	.908	0.44	.037
Anchor class (ref. INSTI)
NNRTI or PI	−0.65	.070	-	-	-	-	-	-

Abbreviations: ART, antiretroviral therapy; BMI, body mass index; cells/uL, cells per microliter; c/mL, copies per milliliter; INSTI, integrase strand transfer inhibitor; NNRTI, non-nucleotide reverse transcriptase inhibitor; PI, protease inhibitor.