Table 1.
Patient demographics.
| Factors | All patients | Group A (2-year death) |
Group B (2-year survival) |
P value |
| Patients, N | 232 | 81 | 151 | N/Aa |
| Age (years), mean (SD) | 85.4 (4.2) | 85.8 (4.0) | 85.3 (4.3) | .41 |
| Sex (male), n (%) | 109 (47) | 36 (44) | 73 (48) | .57 |
| Diabetes mellitus, n (%) | 130 (56) | 51 (62) | 79 (52) | .12 |
| Hypertension, n (%) | 201 (87) | 72 (89) | 129 (85) | .46 |
| Coronary artery disease, n (%) | 93 (40) | 32 (40) | 61 (40) | .90 |
| Congestive heart failure, n (%) | 39 (17) | 19 (24) | 20 (13) | .047 |
| Cerebrovascular accident, n (%) | 52 (22) | 29 (36) | 22 (15) | <.001 |
| Dialysis dependence, n (%) | 57 (25) | 27 (33) | 30 (20) | .02 |
| Smoking history, n (%) | 58 (25) | 19 (24) | 39 (26) | .69 |
| Atrial fibrillation, n (%) | 49 (21) | 20 (25) | 29 (19) | .33 |
| Hyperlipidemia, n (%) | 95 (41) | 31 (39) | 64 (42) | .59 |
| Ambulatory status, n (%) | 83 (36) | 16 (20) | 67 (44) | <.001 |
| CLTIb, n (%) | 192 (83) | 78 (96) | 114 (76) | <.001 |
| Body mass index (kg/m2), mean (SD) | 23.1 (3.5) | 22.3 (3.5) | 23.6 (3.4) | .006 |
| Cholesterol (mg/dL), mean (SD) | 159 (39) | 150 (39) | 163 (39) | .01 |
| Triglyceride (mg/dL), mean (SD) | 117 (70) | 111 (63) | 119 (73) | .46 |
| Glycohemoglobin (%), mean (SD) | 6.51 (1.50) | 6.70 (1.68) | 6.42 (1.41) | .21 |
| Hematocrit (%), median (IQR) | 33.7 (29.8-37.2) | 33.5 (29.9-36.5) | 33.9 (29.8-38.1) | .10 |
| White blood cell count (109/L), median (IQR) | 7.230 (5.673-9.080) | 7.970 (6.720-9.965) | 6.850 (5.120-8.200) | .001 |
| Platelet count (103/μL), median (IQR) | 208 (164-255) | 217 (169-278) | 205 (156-245) | .07 |
| Neutrophil-lymphocyte ratio, median (IQR) | 3.62 (2.34-5.62) | 5.03 (3.31-7.02) | 3.03 (2.04-4.64) | <.001 |
| Platelet-lymphocyte ratio, median (IQR) | 145 (114-219) | 173 (120-243) | 135 (107-195) | .002 |
| Systemic immune-inflammation indexc, median (IQR) | 716 (461-1272) | 1083 (568-1835) | 598 (383-972) | <.001 |
| C-reactive protein (mg/dL), median (IQR) | 1.25 (0.31-4.40) | 3.08 (0.77-8.20) | 0.90 (0.19-2.92) | <.001 |
| Albumin (g/dL), mean (SD) | 3.10 (0.65) | 2.78 (0.63) | 3.26 (0.59) | <.001 |
| CONUTd score, mean (SD) | 4.74 (2.97) | 6.26 (2.81) | 3.93 (2.72) | <.001 |
| Geriatric Nutritional Risk Index, mean (SD) | 89.3 (12.5) | 83.1 (12.3) | 92.6 (11.3) | <.001 |
| Follow-up time (days), median (IQR) | 971 (389-1575) | 229 (79-438) | 1360 (1008-1942) | <.001 |
aN/A: not applicable.
bCLTI: chronic limb-threatening ischemia.
cSystemic immune-inflammation index was defined as (platelet count × neutrophil count)/lymphocyte count.
dCONUT: Controlling Nutritional Status.