Figure 29. Relationship between DAN dendritic inputs and DAN axonal outputs to KCs.
These plots explore whether DANs of the same cell type that have distinct inputs also connect to distinct populations of KCs within a compartment. Analysis of eight compartments is shown. Within each example, the left heatmap represents the similarity of input to DANs (identical to the corresponding block in Figure 27). The right heatmap represents the cosine similarity of the output synapses made by DANs onto KCs. The clustering observed in the right panels most likely results from individual PAM neurons only arborizing in a portion of their compartment (see neuronal morphologies Figure 28—figure supplement 1 and Figure 30). Such clustering may permit specific reinforcement signals to be conveyed to subsets of KCs within a compartment. See detailed discussion of DAN-KC connectivity in Figure 30 and Figure 30—figure supplements 1 and 2. The potential computational significance of this phenomenon is explored in the Discussion (see Figure 38). Additional anatomical information about DAN cell types PAM11 (a1), PAM09 (b1-ped), PAM12 (g3) and PAM07 (g4<g1g2) is presented in Figure 29—video 1, Figure 29—video 2, Figure 29—video 3, Figure 29—video 4, respectively.
