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. 2021 Feb 10;17(2):e1008670. doi: 10.1371/journal.pcbi.1008670

Fig 1. PC dynamics controlled by excitation and inhibition.

Fig 1

(A) Schematic illustration of feedforward excitatory GC-PC short-term plasticity (STP) pathway and inhibitory GC-MLI-PC pathway on a PC. Granular cells (GCs, red), molecular intermediate neurons (MLIs, blue) and Purkinje cells (PCs, black). (B) Postsynaptic currents of four types of synapses from experimental data fitted by models. (C) The PC network with 50 PCs (black), 1000 GCs (red), and 500 MLIs (blue). For illustration, only 3 PCs are shown. (D) PC in response to the GC-PC input. (Left) EPSPs triggered by a single GC spike by varying GC-PC synaptic STP amplitudes Uexc (0.05–0.75 with a 0.05 increment). (Middle) EPSPs triggered by a train of 10 spikes at 200 Hz at two different values of U: Uexc = 0.06 for facilitation and Uexc = 0.42 for depression, with (light blue) and without (purple) STP switched on. (Right) STP described by the ratio EPSPn/EPSP1 showing facilitation or depression in a train of a varying number of burst spikes under different U (0.02-0.7, fixed burst frequency at 200 Hz). (E) Similar to D but for IPSPs triggered by the MLI-PC input. Single IPSPs induced by different strengths WMLI (0.5–7 with a 0.5 increment).