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. 2021 Feb 23;47(4):61. doi: 10.3892/ijmm.2021.4894

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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The expression levels of TH, GPX4 and FTH1 are significantly decreased in rats with PD. (A) The change in the number of rotation laps of the rats after the apomorphine (APO) injection on post-surgical day 28; the number of turns is presented as the mean ± SEM. (B) IHC was performed in the SN of the control and model group. The expression of TH was decreased in the model group. (C) The expression of GPX4 was decreased in the model group. (D) The expression of FTH1 was reduced in the model group. The ratio of positive cells was analyzed. ^*P<0.05, ^**P<0.01 and ^****P<0.0001 vs. model group; scale bar, 50 µm. PD, Parkinson's disease; TH, tyrosine hydroxylase; GPX4, glutathione peroxidase 4; FTH1, ferritin heavy chain 1.