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. 2021 Feb 23;47(4):61. doi: 10.3892/ijmm.2021.4894

Figure 2.

Figure 2

miR-335 promotes ferroptosis in rats with PD. (A) The expression of miR-335 was significantly increased in rats with PD. RT-qPCR was performed to select the most differentially expressed miRNA in the SN of rats. *P<0.05 vs. model group. (B) miR-335 significantly increased the number of rotation laps in rats with PD. The graph on the right panel shows the results of the statistical analysis of findings on the graph on the left panel. miR-335 inhibitor vs. model, *P<0.05. miR-335 mimic vs. model, **P<0.01. (C) miR-335 mimic reduced TH, GPX4 and FTH1 expression levels in rats with PD. *P<0.05, **P<0.01 and ***P<0.001 vs. model group. PD, Parkinson's disease; TH, tyrosine hydroxylase; GPX4, glutathione peroxidase 4; FTH1, ferritin heavy chain 1.