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. 2021 Feb 22;17:613–626. doi: 10.2147/NDT.S289444

Figure 1.

Figure 1

Berberine ameliorated depressive-like behavior in CUMS mice. C57BL/6J mice were received a 5-week CUMS program with or without Berberine treatment. Non-treated mice were used as control. SPT (A) and FST (B and C) were used to evaluate the sucrose preference, swimming time and immobility time of mice. (D and E) MiR-34b-5p and miR-470-5p expression in the hippocampus of CUMS mice and control mice was measured using qRT-PCR. (F and G) QRT-PCR and WB analysis were used to assess BDNF mRNA and protein expression in the hippocampus of CUMS mice and control mice. (H and I) Pearson correlation analysis was used to assess the correlation between BDNF mRNA expression and miR-34b-5p or miR-470-5p expression in the hippocampus of CUMS mice. **P < 0.01, ***P < 0.001, ****P < 0.0001.