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. 2021 Feb 22;17:575–585. doi: 10.2147/NDT.S296451

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© 2021 McIntyre et al.

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Path analysis to estimate direct effects of treatment with vortioxetine on functioning: placebo-controlled studies.

Notes: Indirect effect = –1.56*0.73 = –1.14; total effect = –1.14 + (0.015) = –1.13 ≈ –1.14; percent direct effect = 0.15/–1.14 ≈0%.

Abbreviations: ANH5, 5-item anhedonia subscale; MADRS, Montgomery–Åsberg Depression Rating Scale; PBO, placebo; SDS, Sheehan Disability Scale; VOR, vortioxetine; γ, estimates of effects and associations obtained from the analysis of covariance models.