Table 2.

Demographics and Baseline Clinical Characteristics

	Placebo-Controlled Studies (N=11)					Active-Comparator Study
	Placebo	Vortioxetine 5 mg/day	Vortioxetine 10 mg/day	Vortioxetine 15 mg/day	Vortioxetine 20 mg/day	Vortioxetine 10–20 mg/day	Agomelatine 25–50 mg/day
No. of patients	1769	1002	1022	436	759	253	242
Sex, % female	61.5	62.4	61.0	68.8	63.1	77.1	72.3
Age, years	43 ± 12	43 ± 13	44 ± 12	45 ± 14	43 ± 13	47 ± 12	46 ± 12
MADRS total score	31.9 ± 4.1	32.2 ± 4.2	32.1 ± 4.3	32.5 ± 4.1	31.6 ± 3.9	29.1 ± 4.4	28.7 ± 4.0
MADRS anhedonia score	19.0 ± 2.5	19.1 ± 2.5	18.9 ± 2.5	19.3 ± 2.3	18.8 ± 2.3	17.3 ± 2.4	17.1 ± 2.3
SDS total score	18.3 ± 6.3	18.5 ± 6.5	17.9 ± 6.4	20.2 ± 5.6	18.2 ± 5.9	19.2 ± 5.3	19.3 ± 5.3
SDS social-functioning score	6.5 ± 2.3	6.4 ± 2.4	6.3 ± 2.3	7.1 ± 2.1	6.3 ± 2.2	6.4 ± 2.1	6.5 ± 2.0

Note: All values are mean ± standard deviation unless otherwise indicated.

Abbreviations: MADRS, Montgomery–Åsberg Depression Rating Scale; SDS, Sheehan Disability Scale.