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. 2021 Feb 22;16:1435–1456. doi: 10.2147/IJN.S285999

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© 2021 Qi et al.

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Schematic illustration of the prodrug vesicles for cancer immunotherapy by ICD induction and CD47 blockade. (A) Schematic design of the acidity and MMP-2 dual-responsive prodrug vesicles. (B) Simplified mechanism of prodrug vesicle -mediated chemo-immunotherapy and CD47 blockade to inhibit tumor growth, recurrence, and distant metastasis. Adapted with permission from . Copyright © 2019 John Wiley and Sons.⁹³