Table 3.
Relationship Between Asthma Diagnosis and Hospitalization Outcomes
| Composite end points | Analysis model | Odds ratio (95% confidence interval) | P value |
|---|---|---|---|
| Asthma | |||
| Mortalitya (N = 54) | Univariate | 0.59 (0.49-0.71) | <.001 |
| Multivariable—model 1b | 0.28 (0.19-0.41) | <.001 | |
| Multivariable—model 2c | 0.64 (0.53-0.77) | <.001 | |
| Hospitalizationd (N = 233) | Univariate | 0.82 (0.77-0.87) | <.001 |
| Multivariable—model 1b | 0.93 (0.86-0.99) | <.001 | |
| Multivariable—model 2c | 0.43 (0.28-0.64) | <.001 | |
| ICU admissiona (N = 45) | Univariate | 0.89 (0.64-1.26) | .53 |
| Multivariable—model 1b | 0.98 (0.97-0.98) | <.001 | |
| Multivariable—model 2c | 0.51 (0.41-0.64) | <.001 | |
| Intubationa (N = 28) | Univariate | 0.54 (0.45-0.67) | <.001 |
| Multivariable—model 1b | 0.92 (0.86-1.00) | .05 | |
| Multivariable—model 2c | 0.56 (0.17-1.86) | .35 | |
Abbreviations: BMI, body mass index; COPD, chronic obstructive pulmonary disease; COVID-19, coronavirus disease 2019.
Analysis based on hospitalized patients.
Multivariable model 1—adjusted simultaneously for age, sex, BMI, race, Charlson comorbidity index, COPD, and smoking (current and former).
Multivariable model 2—adjusted simultaneously for age, sex, BMI, race, COVID-19 disease severity, Charlson comorbidity index, COPD, C-reactive protein (>150 mg/L), interleukin-6 (>80 μg/L), ferritin (>2000 ng/L), D-dimer (>2.0 μg/L), use of anticoagulation, use of corticosteroids, and smoking (current and former).
Analysis based on all patients (hospitalized and nonhospitalized patients).