Table 1.
Patient clinical and demographic characteristics.
| Characteristics | All patients | Without allergic reaction | Allergic reaction | p-value | |
|---|---|---|---|---|---|
| Continuous variable: median (interquartile interval) | |||||
| Age at diagnose (years) | 4.5 [3.0; 8.25] | 4.0 [2.75; 8.25] | 5.0 [4.0; 8.5] | 0.406 | |
| Categorical variables: n (%) | |||||
| Sex | |||||
| Male | 60 (61.2) | 45 (54.9) | 15 (93.8) | 0.008 | |
| Female | 38 (38.7) | 37 (45.1) | 1 (6.3) | ||
| Diagnose | |||||
| B- ALL | 86 (88.7) | 72 (87.1) | 14 (87.5) | >0.999 | |
| T-ALL | 11 (11.3) | 9 (11) | 2 (12.5) | ||
| NCI risk classification of leukemia | |||||
| Low risk | 61 (62.9) | 51 (62.2) | 10 (62.5) | >0.999 | |
| High risk | 36 (37.1) | 30 (36.6) | 6 (37.5) | ||
| Concomitant use of corticosteroids – total administrations of ASP: n (%) | |||||
| Yes | 1331 (87.45) | 1319 (87.64) | 12 (70.59) | 0.052 | |
| No | 191 (12.55) | 186 (12.36) | 5 (29.41) | ||
| Use of pre-medication - total administrations of ASP: n (%) | |||||
| Yes | 1192 (78.89) | 1176 (78.71) | 16 (94.12) | 0.145 | |
| No | 319 (21.11) | 318 (21.29) | 1 (5.88) | ||
*p-value was calculated using Mann-Whitney test (age); Yates χ² test (sex, NCI risk classification of leukemia) and Fisher’s exact test (type of leukemia, concomitant use of corticosteroids and use of pre-medication).