Fig. 1. Schematic overview of the transfer-learning procedure.

Biological signatures are transferred across cohorts, to identify biological dimensions that are simultaneously associated with psychosis and somatic comorbidities. Notably, the transfer of illness-signatures across cohorts allows circumventing the requirement of data from patients affected simultaneously by psychosis and comorbid conditions. Rather, subgroup profiles of these conditions are derived independently from disease-specific data and optimized for multivariate overlap in the feature space. COMMITMENT will build on these recent advances to develop a distributed and privacy-preserving computational framework that obviates the need for exchanging raw data across project partners, allowing analysis of the largest possible sample sizes while maintaining data security.