Table 2.
Clinical demographics and brain-PAD results in the initial categorization of patients
| TLE-NL (N = 164) | TLE-HS (N = 63) | Ext-FE (N = 45) | IGE (N = 30) | SGE/PME (N = 5) | PNES (N = 11) | |
|---|---|---|---|---|---|---|
| Age (y) | ||||||
| Mean ± SD | 45.8 ± 16.6 | 43.3 ± 13.7 | 35.9 ± 12.0 | 28.9 ± 7.7 | 31.4 ± 9.8 | 31.5 ± 8.6 |
| Sex (N) | ||||||
| Male:female | 81:83 | 25:38 | 27:18 | 8:22 | 3:2 | 3:8 |
| Disease duration (y) | ||||||
| Mean onset age ± SD | 30.8 ± 20.8 | 14.4 ± 10.9 | 13.3 ± 10.5 | 15.6 ± 6.1 | 10.6 ± 8.7 | 23.6 ± 11.1 |
| Mean duration ± SD | 15.0 ± 13.9 | 29.0 ± 13.5 | 22.6 ± 12.6 | 13.3 ± 9.3 | 20.8 ± 15.7 | 7.8 ± 7.3 |
| Drug-resistance (N, %) | ||||||
| Patients with refractory SZ | 149 (91%) | 61 (97%) | 43 (96%) | 6 (20%) | 5 (100%) | 11 (100%) |
| Brain-age estimation (y) | ||||||
| Mean brain-PAD ± SD | 4.7 ± 7.9 | 8.8 ± 7.3 | 5.6 ± 7.5 | 8.9 ± 6.3 | 21.2 ± 10.0 | 10.6 ± 5.6 |
| Estimated marginal mean ± SE | 3.3 ± 0.5 | 6.9 ± 0.8 | 2.1 ± 0.9 | 3.8 ± 1.1 | 16.7 ± 2.7 | 6.1 ± 1.8 |
TLE-NL temporal lobe epilepsy with visually normal MRI, TLE-HS temporal lobe epilepsy with hippocampal sclerosis, Ext-FE extra-temporal lobe focal epilepsy, IGE idiopathic generalized epilepsy, SGE/PME symptomatic generalized epilepsy or progressive myoclonic epilepsy, PNES psychogenic nonepileptic seizures, SZ seizures, brain-PAD brain-predicted age difference, SE standard error