Fig. 1.

Cardiac phenotype of the A178D mice. a Echocardiographic measurements: fractional shortening, end-systolic and end-diastolic dimensions are shown (Student’s t-test, n = 21/17 WT/A178D, all males, age 99 ± 1 days). For cohort characteristics and a wider set of echocardiographic parameters please refer to Table S3. b Effect of chronic adrenergic stimulation by Iso/PE infusion on cardiac performance in WT and A178D mice. Hypertrophic response to Iso/PE as indicated by LV mass is similar between both genotypes (left). Systolic function of A178D hearts was reduced upon Iso/PE treatment (right). For cohort characteristics and a wider set of echocardiographic parameters please refer to Table S5; (n = 10/9 sham/Iso/PE; Kruskal–Wallis followed by Wilcoxon rank sum test with Bonferroni correction, all males, age 116–120 days)