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a Summary of induction of a proteo-toxic response in 1 year old A178D mice assessed by Western blotting (Mann–Whitney U test, n = 6, age WT 416 ± 2 days, A178D 423 ± 3 days, all male). b Summary of induction of a proteo-toxic response in a cohort undergoing adrenergic challenge assessed by Western blotting. Kruskal–Wallis followed by Wilcoxon rank sum test with Bonferroni correction, n = 6, age 120 ± 2 days, all male. For summary see Table 2 and for individual blots Figs. S29–34
