Table 2.

Summary of results from Western blots for proteo-toxic response on the three different cohorts

Protein (Transcript)	Figure	3 month old	Aged (1 year old)	Iso/PE challenge
Bag3	S29	n.s.	n.s.	↑ (Iso/PE)
Hsp70 (Hspa1a)	S30	n.s.	n.s.	↑ (Iso/PE)
Hsc70 (Hspa8)	S31	n.s.	↑ (also HET)	n.s.
αβ-crystallin (Cryab)	S32	n.s.	↑	n.s.
Hsp27 (Hspb1)	S33	n.s.	↑
Hspb7	S34	n.s.	n.s.	n.s.

Significant changes of homozygous A178D compared to WT (of same treatment group for Iso/PE challenge) are indicated; ↑ upregulation, n.s. not significant

For original blots and quantifications see Figs. S29–34