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General, simplified synthetic routes for the preparation of proinhibitors I, II & III (5, 6 & 7). Synthesis of the binding motif of proinhibitor I (5) was conducted by a solid phase procedure, whereas binding motif 21 was obtained by a mixed solid/solution phase synthesis prior to coupling to compound 18. Compound 22 (proinhibitor III) could only be obtained by solution phase synthesis. Detailed synthesis procedures are given in the supporting information
