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. 2021 Feb 26;11:4809. doi: 10.1038/s41598-021-84355-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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SSJIBL altered the gut microbiota composition of GK rats in a time-dependent manner. (A) Venn map. (B) α diversity of gut microbiota. (C) Bray curtis PCoA analysis of gut microbiota based on the OTU data of Sham and SSJIBL groups. (D) Volcano map of different OTUs. (E) Heatmap of the different OTUs altered by SSJIBL treatment. The color of the spots in the left panel represents the relative abundance of the OTU in each group. The phylum, and genus names of the OTUs are shown on the right panel. The analyses were conducted using R software version 3.6.2.