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. 2021 Feb 26;10(2):17. doi: 10.1038/s41389-021-00307-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Expression level of p-smad2, p-smad3 in BZR cells transfected with the indicated plasmids in response to TGF-β1 (5 ng/ml) for 1 h. b Transwell migration assay on BZR cells transfected with the indicated plasmids in response to TGF-β1 (5 ng/ml). Columns, mean of two independent experiments performed in triplicate; bar, S.D.; ***P < 0.001 versus control. c Syntenin protein expression in BEAS-2B, A549, H358, H1299, and BZR cells. d Real-time RT-PCR analysis of syntenin mRNA levels in BEAS-2B and BZR cells. Data are presented as the mean±s.d. of three independent experiments; bar, S.D.; ***P < 0.001 versus BEAS-2B. e Real-time RT-PCR analysis (upper panel) and western blot analysis (lower panel) of syntenin expression in A549 cells in response to GSK-J4. Columns, mean of three independent experiments performed in triplicate; bar, S.D.; ***P < 0.001 versus control. f Real-time RT-PCR analysis (upper panel) and western blot analysis (lower panel) of JMJD3 and syntenin expression levels in BZR cells in response to knockdown of JMJD3. Columns, mean of three independent experiments performed in triplicate; bar, S.D.; ***P < 0.001 versus control. g Real-time RT-PCR analysis (upper panel) and western blot analysis (lower panel) of JMJD3 and syntenin expression levels in BEAS-2B cells transfected with control or HA-tagged JMJD3. Columns, mean of three independent experiments performed in triplicate; bar, S.D.; ***P < 0.01 versus control. h A representative image of immunohistochemical staining with JMJD3 and syntenin in human lung cancer tissue microarray. Scale bar, 50 μm. i The positive correlation between JMJD3 and syntenin expression in human lung cancer tissues. Pearson’s coefficient tests were performed to assess significance.