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. 2021 Feb 26;12:1337. doi: 10.1038/s41467-021-21583-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Two-dimensional visualization of a dataset that contains 4259 single-cell chromatin profiles from the hippocampus and ventricular zone in embryonic mouse brain (E18) reveals two-branch differentiation trajectories from progenitor cells to Granule Cells (DG) and Pyramidal Neurons (CA3) (left). Data source is listed in Supplementary Table 1. The cellular trajectory is determined using Slingshot. b Gene accessibility score (Methods section) of canonical marker genes is projected onto the 2D embedding.