Fig. 6.

The gut microbiome transforms dietary SA into DHCeramides. Representative structures and HRMS ion chromatograms of alkyne-bearing C15- (A), C15OH- (B), C16OH- (C), C17OH- (D), C18:2- (E), and C22:2-DHCerarmide (F) from the cecal microbial metabolomes of mice orally treated with SAA (blue), but not detected in treatments of SA (green), vehicle, or no treatment (red). The x-axis represents retention time along a reverse phase column, and the y-axis represents relative intensity normalized to the largest peak in the time window.