Table 1.

Osteoarthritis GWAS signals with high posterior probability for co-localisation with molecular QTLs.

GWAS varianta	rs10502437	rs11732213	rs12901372	rs1560707	rs4775006
Osteoarthritis phenotype	All	Hip/Knee	Hip	All	Knee
Risk allele frequency	0.6	0.81	0.53	0.37	0.41
Odds ratio	1.03	1.06	1.08	1.04	1.06
P value	2.50 × 10–8	8.81 × 10–10	3.46 × 10–11	1.35 × 10–13	8.40 × 10–10
Risk allele	A	T	C	T	A
Gene	NPC1	FAM53A	SMAD3	SLC44A2	ALDH1A2
Risk allele effect on gene expression	decrease	decrease	decrease	increase	increase

^aSignals are denoted by their lead variants.