Fig. 3. Age-associated impaired muscle function in Mib1^ΔMF mice.

a To track changes in skeletal muscle function with age, the longitudinal in vivo muscle function analysis was performed. Mib1^WT and Mib1^ΔMF mice were subjected to exercise analysis (whole-limb grip strength test and treadmill running exhaustion test) at 3, 9, and 16 months. b Whole-limb grip strength at indicated ages. c Scheme of treadmill running. d, e Running distance (d) and time (e) to exhaustion at indicated ages. Data are presented as means ± s.e.m. Data are shown as representatives of at least three independent experiments. n = 6 and 5 for Mib1^WT and Mib1^ΔMF mice, respectively (b, d, e). Two-way ANOVA for (b, d, e). *p < 0.05.