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. 2021 Feb 26;12(2):216. doi: 10.1038/s41419-021-03502-4

Fig. 6. Orai1 might contribute to HG-induced cardiomyocyte hypertrophy via activation of CnA, ERK-Drp1 pathways.

Fig. 6

A Changes in CnA levels in NRCMs treated with 10 μM BTP2 (n = 4). B Changes of p-ERK1/2 and total ERK1/2 protein levels in NRCMs treated with BTP2 10 μM (n = 3). C Western blotting images and summarized data showing p-Drp1S616 (n = 4) and p-Drp1S637 (n = 3) protein levels in NRCMs treated with 10 μM BTP2. D Changes of p-Drp1S616 (n = 4) and p-Drp1S637 (n = 4) levels in NRCMs infected with sgOrai1 at 80 MOI for 72 h. The protein levels of phospho-Drp1 (S616/S637) were normalized by total Drp1. Data are shown as mean ± SEM. *P < 0.05, **P < 0.01, and ***P < 0.001; n.s: no significant statistical difference.