Fig. 8. Oscillatory Dll1 expression controls muscle growth in fetal development.

a Immunohistological analysis of distal limb muscles of control and Dll1^type2/type2 mutant animals at E14.5 using the indicated antibodies. The ratio of MyoG+/Pax7+ cells and the quantification of the proliferation of Pax7+ cells (EdU incorporation into Pax7+ cells) is shown to the right (n = 3 animals). b Immunohistological analysis of distal limb muscles of control and Dll1^type2/type2 mutant animals at E17.5 using the indicated antibodies. Quantification of the number of Pax7+ cells in the muscle is shown at the right (n = 3 animals). Scale bars, 100 μm (a) and 200 μm (b). Data are presented as mean values ± SEM. Exact p values are indicated, ns indicates P > 0.05, unpaired two-sided t-test.