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. 2021 Feb 26;12:1318. doi: 10.1038/s41467-021-21631-4

Fig. 9. Oscillatory expression of Dll1, Hes1, and MyoD controls self-renewal and the timing of differentiation.

Fig. 9

a Dll1, Hes1, and MyoD are dynamically expressed in activated muscle stem cells (left). Hes1 is no longer expressed, and Dll1 and MyoD expression are sustained when muscle stem cells differentiate (right). b In contacting cells that are activated, the periodic Dll1 input into the Notch signaling cascade needs to be coordinated between the two cells in order to allow stable oscillations. MSC muscle stem cell.