Figure 1.

Schematic overview of the bioinformatics approaches. A Pipeline 1; SARS-CoV-2 proteins were aligned against > 2500 allergen protein sequences (see methods) and MHC class I-and II- restricted potentially cross-reactive T cell epitope pairs were identified for the most frequent human HLA alleles. B Pipeline 2; In an independent framework, we performed the comparative analysis of sequential kmers from SARS-CoV-2 protein sequences with known IEDB allergen peptides to predict the cross-reactive viral peptide pool.