Table 1.
The Top 5 candidate human HLA class I T cell potentially cross-reactive epitope pairs between SARS-CoV-2 and aero-and food-allergens based on pair combined score and application of additional clinical and conservation related criteria (see Suppl. Fig. 1) (pipeline 1).
| MHC I | Top 30 pair combined score | ||||||
|---|---|---|---|---|---|---|---|
| Candidate | Allergen epitope | Protein family | Viral epitope | MHC allele | pcs | ||
| AERO | Nr.1 | Mus m 1 | GSNTFTILK | Lipocalin | TSNSFDVLK | HLA-A_11_01 | 8188 |
| Nr. 2 | Asp f 5 | MLYEVLWNL | Fungalysin metalloprotease | YLYALVYFL | HLA-A_02_01 | 5974 | |
| Nr. 3 | Aln g 1 | SGVSPVSYQK | Bet v 1 family | ATSRTLSYYK | HLA-A_11_01 | 2413 | |
| Nr.4 | Phl p 5 | KYKTFVATF | Group 5/6 grass pollen allergen | MFDAYVNTF | HLA-A_24_02 | 1910 | |
| Nr. 5 | Mus m 1 | GSNTFTILK | Lipocalin | VTNNTFTLK | HLA-A_11_01 | 3286 | |
| FOOD | Nr. 1 | Gal d 5 | FLGHFIYSV | Serum albumin | TMADLVYAL | HLA-A_02_01 | 1408 |
| Nr. 2 | Gal d 6 | YLLDLLPAA | Lipoprotein | TLMNVLTLV | HLA-A_02_01 | 4185 | |
| Nr. 3 | Gal d 6 | RPAYRRYLL | Lipoprotein | RPPLNRNYV | HLA-B_07_02 | 2274 | |
| Nr. 4 | Cor a 1 | APHGGGSIL | Bet v 1 family | VPGLPGTIL | HLA-B_07_02 | 2571 | |
| Nr. 5 | Gal d 6 | KVFRFSMFK | Lipoprotein | LVASIKNFK | HLA-A_11_01 | 1194 | |
Pcs = pair combined score.