Table 2.

The Top 5 candidate human HLA class II T cell potentially cross-reactive epitope pairs between SARS-CoV-2 and aero-and food-allergens based on pair combined score and application of additional clinical and conservation related criteria (see Fig. 1) (pipeline 1) Pcs = pair combined score.

MHC II		Top 30 pair combined score
		Candidate	Allergen epitope	Protein family	Viral epitope	MHC allele	pcs
AERO	Nr.1	Phl p 5	FVATFGAAS	Group 5/6 grass pollen allergen	FSSTFNVPM	HLA-DRB1_04_01	87
	Nr. 2	Asp f 4	LTALAAGSA	Unclassified	VTALRANSA	HLA-DRB1_01_01	479
	Nr. 3	Phl p 5	FVATFGAAS	Group 5/6 grass pollen allergen	FSSTFNVPM	HLA-DRB1_04_01	53
	Nr.4	Phl p 5	FVATFGPAS	Group 5/6 grass pollen allergen	FSSTFNVPM	HLA-DRB1_04_01	29
	Nr. 5	Phl p 5	FKVAATAAN	Group 5/6 grass pollen allergen	FSSTFNVPM	HLA-DRB1_04_01	38
FOOD	Nr. 1	Gal d 5	FLYAPAILS	Serum albumin	FYILPSIIS	HLA-DRB1_01_01	299
	Nr. 2	Gal d 6	ILVDAVLKE	Lipoprotein	VVADAVIKT	HLA-DRB1_03_01	113
	Nr. 3	Gal d 6	VYSDVPIEK	Lipoprotein	VVADAVIKT	HLA-DRB1_03_01	29
	Nr. 4	Ara h 1	FIMPAAHPV	Cupin	FVMMSAPPA	HLA-DRB1_01_01	258
	Nr. 5	Gal d 5	FLYAPAILS	Serum albumin	FLYENAFLP	HLA-DRB1_01_01	81