Table 3.
HLA-I binding high confidence (IC50 < 50 nm) SARS-CoV-2 antigenic peptides (pipeline 2).
| Allele | HLA-I-Binding Peptide | IC50 | SARS-CoV-2 protein name |
|---|---|---|---|
| HLA-A*68:01 | NIFGTVYEK | 6 | R1AB_SARS2_Replicase_polyprotein |
| HLA-A*02:06 | YTVELGTEV | 9.4 | R1A_SARS2_Replicase_polyprotein |
| HLA-A*68:02 | YTVELGTEV | 10.8 | R1A_SARS2_Replicase_polyprotein |
| HLA-B*15:03 | LASHMYCSF | 10.8 | R1A_SARS2_Replicase_polyprotein |
| HLA-B*40:02 | HEGKTFYVL | 11 | SPIKE_SARS2_Spike_glycoprotein |
| HLA-B*40:01 | GETLPTEVL | 11.9 | R1AB_SARS2_Replicase_polyprotein |
| HLA-A*02:06 | TVYEKLKPV | 13.4 | R1AB_SARS2_Replicase_polyprotein |
| HLA-A*30:02 | ASHMYCSFY | 13.9 | R1A_SARS2_Replicase_polyprotein |
| HLA-B*40:01 | HEGKTFYVL | 13.9 | SPIKE_SARS2_Spike_glycoprotein |
| HLA-A*11:01 | NIFGTVYEK | 24 | R1AB_SARS2_Replicase_polyprotein |
| HLA-B*35:01 | LASHMYCSF | 24.5 | R1A_SARS2_Replicase_polyprotein |
| HLA-A*68:02 | TVYEKLKPV | 26 | R1AB_SARS2_Replicase_polyprotein |
| HLA-A*02:01 | WLTNIFGTV | 34.1 | R1AB_SARS2_Replicase_polyprotein |
| HLA-A*02:06 | WLTNIFGTV | 34.7 | R1AB_SARS2_Replicase_polyprotein |
| HLA-B*15:03 | LTNIFGTVY | 35.7 | R1AB_SARS2_Replicase_polyprotein |
| HLA-B*15:25 | LASHMYCSF | 39.1 | R1A_SARS2_Replicase_polyprotein |
| HLA-B*15:25 | LTNIFGTVY | 39.8 | R1AB_SARS2_Replicase_polyprotein |
| HLA-A*02:01 | TVYEKLKPV | 47.8 | R1AB_SARS2_Replicase_polyprotein |
| HLA-B*15:01 | LASHMYCSF | 48.1 | R1A_SARS2_Replicase_polyprotein |
| HLA-B*15:03 | ASHMYCSFY | 49 | R1A_SARS2_Replicase_polyprotein |