Table 3. Changes in Antibiotic Use Comparing November-December 2018 With January-February 2018 Across 402 Hospitals Participating in the AHRQ Safety Program^a.

Variable	No.	DOT per 1000 patient-days		Mean difference (95% CI)	P value
		Jan-Feb	Nov-Dec
Use in all hospitals
All antibiotics	402	900.7	870.4	−30.3 (−52.6 to −8.0)	.008
Fluoroquinolones	402	105.0	84.6	−20.4 (−25.4 to −15.5)	.009
Antibiotic use
In academic medical centers	28	854.4	808.4	−46.0 (−101.8 to 9.8)	.11
In nonacademic medical centers	374	906.8	878.7	−28.1 (−52.2 to −3.9)	.02
Antibiotic use in hospitals
With ≤100 beds	165	888.2	863.7	−24.5 (−65.3 to 16.3)	.24
With 101-299 beds	136	875.6	850.9	−24.7 (−61.8 to 12.4)	.19
With ≥300 beds	101	939.6	896.8	−42.8 (−78.0 to −7.6)	.02
Antibiotic use
In general wards	311	851.4	828.5	−22.9 (−48.6 to 2.8)	.08
In intensive care units	165	1001.9	962.7	−39.2 (−82.9 to 4.6)	.08
Antibiotic use in hospitals
Adherent to all 4 key components of antibiotic stewardship at baseline	32	876.5	826.9	−49.6 (−106.3 to 7.1)	.09
Not adherent to all 4 key components of antibiotic stewardship at baseline	370	903.9	875.9	−28.0 (−52.0 to −3.9)	.02

Abbreviations: AHRQ, Agency for Healthcare Research and Quality; DOT, days of antibiotic therapy.

^aData analysis occurred using linear mixed models with random hospital unit effects.