Table 1.
Summary of capsid-binding host cell factors.
| Abbreviation | Name | Binding Site on CA | Related Process | Complex PDB ID |
|---|---|---|---|---|
| ATP | Adenosine triphosphate | R18 pore | Reverse Transcription | - |
| BICD2 | Bicaudal D2 | - | Trafficking | - |
| CLASP2 | Cytoplasmic linker-associated protein 2 | - | Trafficking | - |
| CLIP170 | Cytoplasmic linker protein 170 | EB1-like domain at pentamer interface | Trafficking | - |
| CPSF6 | Cleavage and polyadenylation specificity factor 6 | Interprotomer Pocket | Nuclear Import and Localization | 4WYM |
| CypA | Cyclophilin A/Peptidylprolyl isomerase A | CypA loop (residues 85 to 93)/Inter-hexamer interface | Uncoating | 5FJB 6Y9W 6Y9V |
| Daxx | Death domain-associated protein | CA-CypA complex | Uncoating Inhibition | - |
| dNTP | Deoxynucleoside triphosphate | R18 pore | Reverse Transcription | - |
| DRFs | Diaphanous-related formins | - | Uncoating/Trafficking | - |
| ERK2 | Extracellular signal-regulated kinase 2 | Phosphorylates Ser-16 of CA | Uncoating | - |
| FEZ1 | Fasciculation and elongation protein zeta-1 | R18 pore | Trafficking | - |
| IP6 | Inositol Hexaphosphate | R18 pore | Reverse Transcription | 6ES8 6BHT |
| MAP1A/MAP1S | Microtubule-associated proteins 1A and 1S | Monomeric CA interface | Trafficking | - |
| MELK | maternal embryonic leucine zipper kinase | Phosphorylates Ser-149 of CA | Uncoating | - |
| MxB | Myxovirus resistance protein B | Inter-hexamer interface | Uncoating Inhibition/Nuclear Import Inhibitor | - |
| NONO | Non-POU domain-containing octamer-binding protein | CA NTD | cGAS Response | - |
| NUP153 | Nucleoporin 153 | Interprotomer Pocket | Nuclear Import | 4U0C 6AYA |
| NUP358 | Nucleoporin 358 | CA NTD | Nuclear Import | 4LQW |
| PDZD8 | PDZ domain-containing protein 8 | Gag | Uncoating | - |
| Pin1 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Phosphorylated Ser-16 of CA | Uncoating | - |
| REAF | RNA-associated early-stage antiviral factor | - | Uncoating Inhibitor/Reverse Transcription Inhibitor | - |
|
TNPO3/
TRN-SR2 |
Transportin 3 | CA-CPSF6 complex | Uncoating, Nuclear Import and Integration | - |
| TRIM11 | Tripartite motif-containing protein 11 | - | Uncoating | - |
| TRIM34 | Tripartite motif-containing protein 34 | - | Reverse Transcription Inhibition | - |
| TRIM5α | Tripartite motif-containing protein 5 | Capsid lattice near CypA binding loop | Uncoating Inhibition | - |
| TRN1 | Transportin 1 | CypA binding loop (G89 crucial) | Nuclear Import | - |