Table 4.
Association between small EV characteristics and overall survival.
| Small EV Characteristics | HR (95% CI) * | p-Value | HR (95% CI)adj * | p-Valueadj | |
|---|---|---|---|---|---|
| Before surgery | Concentration (×1010/mL) |
1.00 (1.00–1.00) | 0.458 | 1.00 (1.00–1.00) | 0.220 |
| Mean diameter (nm) | 1.03 (0.77–1.36) | 0.865 | 1.10 (0.81–1.50) | 0.551 | |
| Modal diameter (nm) | 0.95 (0.79–1.14) | 0.571 | 1.08 (0.87–1.34) | 0.486 | |
| Median diameter (nm) | 0.98 (0.76–1.28) | 0.904 | 1.07 (0.79–1.44) | 0.663 | |
| Relative change | Concentration (%) | 1.11 (0.98–1.27) | 0.106 | 1.25 (1.05–1.50) | 0.015 |
| Mean diameter (%) | 0.65 (0.40–1.05) | 0.076 | 0.69 (0.44–1.10) | 0.117 | |
| Modal diameter (%) | 0.86 (0.68–1.08) | 0.197 | 0.74 (0.57–0.95) | 0.019 | |
| Median diameter (%) | 0.76 (0.50–1.16) | 0.199 | 0.76 (0.52–1.12) | 0.165 |
HR: hazard ratio; CI: confidence interval; adj: adjusted for CRP levels before surgery and adjuvant chemotherapy. * HR values are reported for a difference of 10 units or 10%.