Figure 7.

Post-transcriptional regulation of p53 by Kaposi’s Sarcoma Herpesvirus (KSHV) viral proteins. (A): Viral RNA isoforms produce several proteins that bind to p53 in different regions and suppress its activity. (B): p53 phosphorylation is regulated by the binding of vCyclin, LANA1, LANA2 and vIRF1 at different regions. LANA1, LANA2 and vIRF1 inhibit the phosphorylation whereas vCyclin induces it. p53 protein plays vital roles in cell cycle regulation, and with loss of function of p53, KSHV induces carcinogenesis [36,82,83].