Table 1.
Summary of current (black), completed (green), and withdrawn (red) clinical trials listed on www.clinicaltrials.gov.
| Cancer | NCT Number | Phase | Treatment | Specifically Inhibited by ISR |
|---|---|---|---|---|
| Bladder | NCT02723838 | I | Pelareorep/Reolysin/Reovirus Gemcitabine Cisplatin |
Gemcitabine: [20] Cisplatin: [21,22] |
| Bone and soft tissue | NCT00503295 | II | Pelareorep/Reolysin/Reovirus | |
| Brain | NCT00528684 | I | Pelareorep/Reolysin/Reovirus | |
| NCT02444546 | I | Pelareorep/Reolysin/Reovirus GM-CSF |
||
| Breast | NCT01656538 | II | Pelareorep/Reolysin/Reovirus Paclitaxel |
Paclitaxel: [23] |
| NCT04102618 | I | Pelareorep/Reolysin/Reovirus Letrozole Atezolizumab Trastuzumab |
||
| NCT04445844 | II | Pelareorep/Reolysin/Reovirus Retifanlimab |
||
| NCT04215146 | II | Pelareorep/Reolysin/Reovirus Avelumab Paclitaxel |
Paclitaxel: [23] | |
| Colorectal | NCT01274624 | I | Pelareorep/Reolysin/Reovirus Irinotecan Leucovorin Fluorouracil Bevacizumab |
Fluorouracil: [24] |
| NCT01622543 | II | Pelareorep/Reolysin/Reovirus Folfox Bevacizumab |
||
| Head and neck | NCT00753038 | II | Pelareorep/Reolysin/Reovirus Carboplatin Paclitaxel |
Paclitaxel: [23] |
| NCT01166542 | III | Pelareorep/Reolysin/Reovirus Carboplatin Paclitaxel |
Paclitaxel: [23] | |
| Lung | NCT01708993 | II | Pelareorep/Reolysin/Reovirus Pemetrexed Docetaxel |
Pemetrexed: [25] Docetaxel: [26] |
| NCT00861627 | II | Pelareorep/Reolysin/Reovirus Carboplatin Paclitaxel |
Paclitaxel: [23] | |
| NCT00998192 | II | Pelareorep/Reolysin/Reovirus Paclitaxel Carboplatin |
Paclitaxel: [23] | |
| Melanoma | NCT00984464 | II | Pelareorep/Reolysin/Reovirus Carboplatin Paclitaxel |
Paclitaxel: [23] |
| NCT00651157 | II | Pelareorep/Reolysin/Reovirus | ||
| NCT03282188 | I/II | Pelareorep/Reolysin/Reovirus GM-CSF |
||
| Myeloma | NCT01533194 | I | Pelareorep/Reolysin/Reovirus | |
| NCT02514382 | I | Pelareorep/Reolysin/Reovirus Bortezomib Dexamethasone |
Bortezomib: [27,28] | |
| NCT03015922 | I | Pelareorep/Reolysin/Reovirus Lenalidomide Pomalidomide |
||
| NCT02101944 | I | Pelareorep/Reolysin/Reovirus Carfilzomib Dexamethasone |
||
| NCT03605719 | I | Pelareorep/Reolysin/Reovirus Carfilzomib Dexamethasone Nivolumab |
||
| Ovarian or fallopian tube | NCT00602277 | I | Pelareorep/Reolysin/Reovirus | |
| NCT01199263 | II | Pelareorep/Reolysin/Reovirus Paclitaxel |
Paclitaxel: [23] | |
| Pancreatic | NCT02620423 | I | Pelareorep/Reolysin/Reovirus Gemcitabine Irinotecan Leucovorin Fluorouracil Pembrolizumab |
Gemcitabine: [20] Fluorouracil: [24] |
| NCT00998322 | II | Pelareorep/Reolysin/Reovirus Gemcitabine |
||
| NCT01280058 | II | Pelareorep/Reolysin/Reovirus Carboplatin Paclitaxel |
Paclitaxel: [23] | |
| NCT03723915 | II | Pelareorep/Reolysin/Reovirus Pembrolizumab |
||
| Prostate | NCT01619813 | II | Pelareorep/Reolysin/Reovirus Docetaxel, Prednisone |
Docetaxel: [26] |
| Unspecified | NCT01240538 | I | Pelareorep/Reolysin/Reovirus Cyclophosphamide |