Table 4.
The results of the study of the effect of motherwort extracts on the behavioral responses of laboratory rats in the open-field test.
| The Experimental Group of Animals | The Number of the Actions Recorded | |||||||
|---|---|---|---|---|---|---|---|---|
| Crossings | Upright Postures | Peeking into Holes | Exploratory Activity: ∑ Postures + Holes |
Defecation | Urination | Washing | Emotional Response: ∑ Boluses + Urination + Grooming |
|
| Control | 28.67 ± 1.75 | 5.67 ± 0.52 | 3.83 ± 0.82 | 4.75 ± 1.14 | 2.50 ± 0.84 | 2.00 ± 0.63 | 1.83 ± 0.75 | 2.11 ± 0.76 |
| Extract | ||||||||
| With lysine | 39.17 ± 4.45 * | 8.00 ± 0.63 *,## | 4.00 ± 0.89 | 6.00 ± 2.22 | 1.17 ± 0.41 *,# | 1.67 ± 0.52 | 1.17 ± 0.41 | 1.33 ± 0.49 *,# |
| With aspartic acid | 38.67 ± 14.53 | 8.0 ± 1.79 ** | 2.83 ± 0.75 | 5.42 ± 3.06 | 1.17 ± 0.41 *,# | 1.50 ± 0.55 | 1.33 ± 0.82 | 1.33 ± 0.59 *,# |
| With leucine | 17.00 ± 6.20 *,# | 3.00 ± 1.67 *,# | 2.17 ± 0.75 * | 2.58 ± 1.31 *,# | 1.17 ± 0.41 *,# | 1.17 ± 0.41 **,## | 1.33 ± 0.52 | 1.22 ± 0.43 *,# |
| With alanine | 18.17 ± 1.17 *,# | 4.17 ± 0.75 *,## | 1.67 ± 0.52 *,## | 2.92 ± 1.44 *,## | 3.83 ± 1.17 **,## | 1.17 ± 0.41 **,## | 0.83 ± 0.41 **,## | 1.94 ± 1.55 |
| With phenylalanine | 33.33 ± 4.97 | 7.83 ± 4.88 | 6.33 ± 0.82 *,# | 7.08 ± 3.42 ** | 2.50 ± 0.84 | 1.33 ± 0.52 | 1.50 ± 0.84 | 1.78 ± 0.88 |
| Control | 21.67 ± 1.21 | 4.67 ± 0.82 | 2.83 ± 0.75 | 3.75 ± 1.22 | 2.33 ± 0.82 | 2.00 ± 0.63 | 1.67 ± 0.82 | 2.00 ± 0.77 |
| Extract | ||||||||
| With glycine | 62.50 ± 1.87 *,# | 7.83 ± 1.17 * | 5.17 ± 1.17 *,## | 6.50 ± 1.78 *,## | 1.33 ± 0.52 **,# | 1.00 ± 0.00 **,## | 1.17 ± 0.41 | 1.17 ± 0.38 *,# |
| With valine | 71.33 ± 4.80 *,# | 7.17 ± 1.17 * | 5.00 ± 0.63 *,## | 6.08 ± 1.44 * | 1.50 ± 0.55 # | 0.83 ± 0.41 *,# | 1.17 ± 0.41 | 1.17 ± 0.51 *,# |
| With histidine | 48.50 ± 2.74 *,# | 6.33 ± 1.03 ** | 2.50 ± 0.55 | 4.42 ± 2.15 | 1.67 ± 0.52# | 1.33 ± 0.52 | 1.33 ± 0.52 | 1.44 ± 0.51 **,# |
| With glutamic acid | 46.67 ± 2.16 *,# | 5.50 ± 1.05 | 1.50 ± 0.55 * | 3.50 ± 2.24 | 1.00 ± 0.00 **,# | 1.00 ± 0.00 *,# | 1.33 ± 0.52 | 1.11 ± 0.32 *,# |
| Control | 23.50 ± 1.87 | 4.50 ± 0.84 | 2.50 ± 1.05 | 3.50 ± 1.38 | 2.83 ± 0.75 | 2.17 ± 0.75 | 2.17 ± 0.75 | 2.39 ± 0.78 |
| Extract | ||||||||
| With arginine | 42.50 ± 2.88 * | 6.67 ± 1.21 * | 5.83 ± 1.47 *,# | 6.25 ± 1.36 *,## | 2.33 ± 1.03 | 1.17 ± 0.41 **,## | 1.67 ± 0.82 | 1.72 ± 0.89 ** |
| With cysteine | 39.00 ± 7.95 * | 6.33 ± 1.03 * | 4.00 ± 1.10 ** | 5.17 ± 1.59 ** | 1.67 ± 0.52 **,## | 1.50 ± 0.55 | 1.33 ± 0.52 | 1.50 ± 0.51 *,# |
| With methionine | 29.67 ± 3.01 *,# | 6.83 ± 0.75 * | 4.17 ± 1.17 ** | 5.50 ± 1.68 * | 3.00 ± 0.89 | 1.33 ± 0.52 | 1.17 ± 0.41 ** | 1.83 ± 1.04 |
| With the motherwort tincture (reference) | 39.67 ± 1.63 * | 6.17 ± 1.47 ** | 2.17 ± 0.75 | 4.75 ± 1.96 | 2.33 ± 0.52 | 2.00 ± 0.63 | 1.83 ± 0.75 | 2.06 ± 0.64 |
*—significant compared to the control group at p < 0.01; **—significant compared to the control group at p < 0.05; #—significant compared to the reference drug group at p < 0.01; ##—significant compared to the reference drug group at p < 0.05.