Table 1.

Presence of CB₁R and CB₂R in human tissues [47,48,49].

Concentration Tissue	CB1R	CB2R
Adrenals	+ +	0
Appendix	+ +	+ +
Bone marrow	Low	+
Brain	+ + + +	0
Colon	+	Low
Duodenum	+	Low
Endometrium	+	Very low
Esophagus	+	Very low
Fat	+ + +	0
Gall bladder	+
Heart	Low	0
Kidney	Very low	0
Liver	0	Very low
Lung	+ +	Low
Lymph node	+ +	+ + +
Ovary	+	0
Pancreas	Very low	0
Placenta	+ +	Very low
Prostate gland	+	Low
Salivary gland	+	Very low
Skin	+	Very low
Small intestine	+	Low
Spleen	+	+ + +
Stomach	+	+
Testis	+	Low
Thyroid	+	Low
Urinary bladder	+	+

RNA-sequencing. RPKM, reads per kilobase million. 0, absent; very low, concentrations equal and below 0.03 RPKM; low, concentrations in the range of 0.119–0.031 RPKM; +, concentrations in the range of 0.582–0.200 RPKM; + +, concentrations in the range of 1.272–1.089 RPKM; + + +, concentrations in the range of 3.665–2.735 RPKM; + + + +, concentration equal to 6.155 RPKM; CB1R—cannabinoid receptor type 1; CB2R—cannabinoid receptor type 2.