TABLE 1.
BNN27 concentrations over time
| Time (h) | CSerum (ng/ml) in mice (dose = 100 mg/kg) |
AUC (ng×h/ml) |
AUMC (ng×h2/ml) |
CRetina (ng/g) in rats (dose = 30 mg/kg) |
AUC (ng×h/g) |
AUMC (ng×h2/g) |
|---|---|---|---|---|---|---|
| 0 | 9026.7 (744.08) | 0 | 0 | <LOD | ||
| 0.25 | – | – | – | <LOD | 0 | 0 |
| 0.5 | 7838.2 (312.87) | 4216.22 | 979.78 | 230 (100) | 28.75 | 14.38 |
| 1 | 6064.4 (393.4) | 7691.86 | 3475.64 | 730 (180) | 268.75 | 225.63 |
| 2 | 907.1 (83.31) | 11 177.6 | 7414.95 | 1.100 (130) a | 1183.75 | 1690.63 |
| 4 | 542.9 (180.48) | 12 627.64 | 11 400.81 | 170 (160) | 2453.75 | 4570.63 |
| 6 | 152.9 (16.88) | 13 323.44 | 14 489.8 | <LOD | 2623.75 | 5250.63 |
| 24 | 26.9 (0.44) | 14 941.64 | 28 556.8 | <LOD | 2623.75 | 5250.63 |
| ∞ | 15 107.97 | 32 548.76 | 2623.75 | 5250.63 |
Note: BNN27 concentration in C57BL/6 mice serum (Cserum, ng/ml) and in S‐D rat retina (Cretina, ng/g), following i.p. injection of 100 and 30 mg/kg doses, respectively, over time (h). Concentration values represent the mean (SEM). AUC and AUMC values are included for each set of values.
Abbreviations: AUC, area under the curve; AUMC, area under the first moment curve.
a
The corresponding value measured at this time point, after transcardial perfusion of 5 animals with Ringer's‐Lactate solution is 320 (70) ng/g.